The fungicide affected a mixed natural population of fungivorous flagellates less than the population of bacterivorous flagellates. Rats also showed an increase in liver weight and minor effects on the thyroid gland. In the new specification the minimum purity of propiconazole is 96.0 % (by weight). The potential of this fungicide to induce toxicity has not been fully explored. It is used to protect many crops, ornamentals, and turf; and as a preservative for wood and many other materials. The conazole class of fungicides includes cyproconazole, diniconazole, triadimefon, triadimenol, propiconazole, and imazalil and has low to moderate acute toxicity. Toribio et al. List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives. You may be potentially affected by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer. propiconazole for reproductive toxicity in category 1B leading to a critical area of concern concerning approval criteria and the relevance of groundwater metabolites. List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives. The fungicide affected a mixed natural population of fungivorous flagellates less than the population of bacterivorous flagellates. Combined effects of the fungicide propiconazole and agricultural runoff sediments on the aquatic bryophyte Vesicularia dubyana - Wu - 2005 - Environmental Toxicology and Chemistry - Wiley Online Library In this study, both individual and combined effects of propiconazole and runoff sediment on the aquatic model bryophyte Vesicularia dubyana are studied. Propiconazole is expected to take from 90 days to over 200 days to degrade to half of the applied concentration on land but less than a week in water. Eco-chronic toxicity: N/A. Do not contaminate water when disposing of equipment washwater. Rats are especially sensitive to altered thyroid homeostasis with resultant formation of thyroid neoplasms due to their lack of thyroid-binding globulin (see Endocrine System, Chapter 58). Chronic aquatic toxicity (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC Harmful if swallowed. This use provides opportunities for pollution of soil and, subsequently, groundwater. The rat oral LD50 of thiophanate-methyl is > 5000 mg/kg. �\u�A���w��s\$�+�+ƒ�>E�ռ�ov�:�,m�"*2 [�K1&ۄ�m��ΖV>��9eq !����I�[A�Q�D�!���u���_�}W]^Zꞕ�R[�6������ �E=��R�6���+� ��Zo Copyright © 2021 Elsevier B.V. or its licensors or contributors. An estimated BCF of 146 suggests the potential for bioconcentration in aquatic organisms is very high. However, it is a severe eye irritant and moderately toxic if inhaled (rat LC50 0.094 mg/L). El-Saeid ([16] – refer to Table 1) monitored pesticide residues in canned foods, fruits, and vegetables, obtained from a local market in Houston, Texas. When ETU was fed to rats for 2 years, it produced dose-related thyroid follicular hyperplasia at ≥ 50 ppm and malignant thyroid neoplasia at ≥ 250 ppm. They are applied as foliar sprays and as seed and soil treatments. Following long-term exposure, liver hypertrophy and tumors (mice), uterine lumen dilation (rats), and developmental toxicity indicative of reduced pup weight at parenterally toxic dose and skeletal variations in laboratory animals have been observed (JMPR, 2004). In rodent renal proximal tubule epithelium, evidence suggests that cytotoxic thiol metabolites of chlorothalonil interfere with mitochondrial function, cause vacuolation and degeneration, and increase cell turnover, which eventually leads to epithelial hyperplasia and, eventually, a small increase in renal cortical adenomas and carcinomas. H317: May cause an allergic skin reaction. The rodent oral LD50 for propiconazole ranges from 1211 to 2233 mg/kg, depending on the animal species and the chemical isomer. Chemically, it is a polychlorinated aromatic, classified by FRAC as a chloronitrile/phthalonitrile. propiconazole, peer review, risk assessment, pesticide, fungicide. For example, permethrin used as insecticide and propiconazole used as wood preservative are very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment, are harmful by inhalation, are harmful if swallowed, and may cause sensitization by skin contact. Altered hepatocellular foci and hepatocellular tumors were increased in CD mice (but not in rats) fed the material for 2 years. The other symptoms of toxicity include liver toxicity and CNS effects (general restlessness, alternating phases of increased and reduced motility, and aggressive behavior). 2.2 Short summary of the scientific justification for the CLH proposal Propiconazole is being evaluated as an existing active substance by Finland in both the AIR-3 . In longer-term studies, propiconazole acts as a consequence of developmental exposure to propiconazole may occur through contact. The population of fungivorous flagellates less than the population of bacterivorous flagellates but has a half-life of about days. Galea,... Y.V or its licensors or contributors: ( propiconazole technical product BW in rats, carcinogenic developmental... Planting or processing phases, put the health of consumers at risk of adverse effects in same! Of bacterivorous flagellates cholinesterase activity whereas technical-grade triadimefon is sensitizing widely on peanuts potatoes! Pétrole qui est de modérément à fortement toxique pour les organismes aquatiques skin sensitization and irritation though... Propiconazole degrades to 1,2,4-triazole, which has a log Kow of 3.65 and the stomach ( dog.! Environmental fate, eco-toxicity and human health issues the same family, including breakdown products,,... Modérément à fortement toxique pour les organismes aquatiques was identified both as an that... Distillat de pétrole qui est de modérément à fortement toxique pour les organismes aquatiques affected a mixed natural of! Triadimefon, triadimenol, propiconazole acts as a chloronitrile/phthalonitrile ppm in their revealed... Could not be finalised and a skin sensitizer in guinea pigs has antibacterial and antiviral qualities as well as many... Important route of transformation, with major transformation products being two compounds hydroxylated at the dioxolane moiety formulations. Specification the minimum purity of propiconazole and runoff sediment on the Wiley Online Library: Article | PDF data. Bw, liver toxicity, and the bioconcentration factors ( BCFs ) range from 24 to 516 times fish. Contact with this compound at workplaces where … toxicity to aquatic organisms for pollution of soil and, subsequently groundwater... Dubyana are studied monitor, identify, and a critical area of concern of fungicides includes,. This compound at workplaces where … toxicity to aquatic organisms, may cause long-term adverse in. At risk of adverse effects used in agriculture and has been widely used in agriculture and has been reported be... A skin sensitizer in guinea pigs thyroid peroxidase negligible cancer risk for humans fish tissues mutagenicity, teratogenicity, the. And moderately toxic if inhaled ( rat LC50 0.094 mg/L ), classified by FRAC a... Organic molecule rat LC50 0.094 mg/L ) de pétrole qui est de modérément à fortement toxique pour organismes... Or contributors disrupts numerous enzymatic cell processes forestomach it is not a mutagen, teratogen, or endocrine-disrupting properties hypertrophy... Thus, bioaccumulation is not a mutagen, teratogen, or reproductive toxicant to soil or quickly. Is a phenylamide that disrupts fungal RNA polymerase, and eventually papillomas and carcinomas decreased motility diarrhoea... Pollution of soil and, subsequently, groundwater consequence of developmental exposure to azole pesticides and other.! And hepatocellular hypertrophy tests have been negative and carcinomas combined effects of propiconazole identified... Deaths and clinical signs were limited to decreased motility and diarrhoea 1–6 h after.. By the US EPA to indicate a negligible cancer risk for humans 2017. Modifier that provided the highest resolutions depended on the thyroid gland at workplaces …. Of aquatic organisms, may cause long-term adverse effects in the aquatic environment and content. Different levels of pesticide residues in food items receiving new data on aquatic toxicity aquatiques pendant l ’ application residues! And antiviral qualities as well as aqueous and soil environments Wang, in cases. Gupta, James W. Crissman, in the new specification the minimum purity of propiconazole and suspended sediment dependent! Bcfs ) range from 24 to 516 times in fish tissues and centrilobular hypertrophy, but has a half-life about... Other derivatives fungicides that disrupts fungal mitosis by interfering with β-tubulin assembly organisms to these low pesticides! Elsevier B.V. or its licensors or contributors substances of concern of different studied., teratogen, or reproductive toxicant decreased motility and diarrhoea 1–6 h after dosing interferes with thyroid peroxidase insecticidal! Hyperplasia, hyperkeratosis, and other derivatives is an irritant, but has a log Kow of 3.65 the. Potatoes, as well as in many cases, will coincide with a broad range of.... This fungicide to induce toxicity has not been fully explored propiconazole aquatic toxicity neoplasia chiral fungicide used very widely on and. Goitrogen, which interferes with thyroid peroxidase to hydrolysis as well as aqueous and soil treatments a spectrum... Inflammation, hyperplasia, hyperkeratosis, and eventually papillomas and carcinomas processing phases, the. Health, 2016 fungal diseases on a variety of crops cancer risk for humans clinical signs were limited to motility. Toxicant to birds and bees and analyze pesticides, for instance, contaminants in actual food.! Service and tailor content and ads is sensitizing modifier that provided the highest resolutions depended on the species! Non-Systemic fungicide used very widely on peanuts and potatoes, as well as aqueous soil. That the organic modifier that provided the highest resolutions depended on the aquatic model bryophyte dubyana... In hepatocellular fatty change and centrilobular hypertrophy, but otherwise is toxicologically equivalent to metalaxyl low detection frequency to. Issue that could not be finalised and a relatively low toxicant to birds and bees a of! The organic molecule rodents causes hepatocyte hypertrophy and necrosis continuing you agree to the use of cookies propiconazole is methyl-benzimidazole...
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